Single-cell Genomics for Biomedicine

Single-cell genomics has transformed biomedical research by enabling the detailed analysis of individual cells, revealing cellular heterogeneity and identifying rare cell types often masked in bulk studies. In cancer biology, it offers critical insights into tumor evolution, clonal diversity, and the tumor microenvironment, facilitating the discovery of biomarkers and development of personalized therapies. Integrating genomic and transcriptomic data at the single-cell level helps decode gene regulation and cell-specific expression patterns. This technology is also advancing fields like immunology, neuroscience, and developmental biology. Although challenges such as data complexity and high costs remain, ongoing innovations in multi-omics and spatial transcriptomics are expanding its capabilities. Single-cell genomics is now essential for precision medicine and understanding complex biological systems.